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AF615

Chemical Structure : AF615

CAS No.: 122510-61-6

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AF615 (AF-615)

Catalog No.: PC-38705Not For Human Use, Lab Use Only.

AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AF615 is a potent and selective small-molecule inhibitor targeting the CDT1/Geminin protein complex with Ki of 0.37 uM aginst Geminin-tCDT1 interaction, inhibits inhibit Geminin/CDT1 complex formation in vitro with IC50 of 0.313 uM.
    AF615 inhibits CDT1-Geminin protein-protein interaction, induces DNA damage and blocks DNA synthesis in cancer cells.
    AF615 reduces viability selectively in cancer cell lines.

    Physicochemical Properties

    M.Wt 267.307
    Formula C10H13N5O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N'-(morpholine-4-carbonothioyl)pyrazine-2-carbohydrazide

    References

    1. Karantzelis N, et al. Front Pharmacol. 2022 Apr 25;13:860682.

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