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GO-Y078

Chemical Structure : GO-Y078

CAS No.: 1217503-60-0

GO-Y078

Catalog No.: PC-38722Not For Human Use, Lab Use Only.

GO‐Y078 is a curcumin analog that suppresses angiogenesis through the inhibition of actin stress fiber formation, inhibits human umbilical venous epithelial cells resistant to angiogenesis inhibitors (HUVEC‐R) at 0.75 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

GO‐Y078 is a curcumin analog that suppresses angiogenesis through the inhibition of actin stress fiber formation, inhibits human umbilical venous epithelial cells resistant to angiogenesis inhibitors (HUVEC‐R) at 0.75 uM.
GO‐Y078 decreases fibronectin 1 (FN1) gene expression.
GO‐Y078 inhibits angiogenesis through other pathways besides the VEGF pathway.

Physicochemical Properties

M.Wt 400.427
Formula C22H24O7
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1E,4E)-1-(4-Hydroxy-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,4-pentadiene-3-one

References

1. Kazuhiro Shimazu, et al. Cancer Sci. 2018 Oct;109(10):3285-3293.

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