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PAT1inh-B01

Chemical Structure : PAT1inh-B01

CAS No.: 1775330-54-5

PAT1inh-B01

Catalog No.: PC-38753Not For Human Use, Lab Use Only.

PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.
    PAT1inh-B01 displays no inhibition of the related intestinal transporter SLC26A3 (also known as DRA).
    In closed midjejunal loops in mice, PAT1inh-B01 inhibited fluid absorption by 50%, which increased to >90% when coadministered with DRA inhibitor DRAinh-A270.
    PAT1inh-B01 blocked fluid absorption by >80% in ileal loops, SLC26A3 inhibitor DRAinh-A270 had no effect.
    PAT1inh-B01 is a novel tool to study intestinal ion and fluid transport.

    Physicochemical Properties

    M.Wt 535.325
    Formula C22H18BrF3N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    7-[2-[4-Bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-5,6,7,8-tetrahydro-2-phenylpyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one

    References

    1. Cil O, et al. JCI Insight. 2021 Jun 8;6(11):e147699.

    2. Lee S, et al. J Med Chem. 2019;62(17):8330–8337.

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