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LSALT peptide

Chemical Structure : LSALT peptide

CAS No.: 2567713-50-0

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LSALT peptide (Metablok)

Catalog No.: PC-38773Not For Human Use, Lab Use Only.

Metablok (LSALT peptide) is a specific DPEP1-binding peptide and nonenzymatic dipeptidase-1 (DPEP-1) inhibitor.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Metablok (LSALT peptide) is a specific DPEP1-binding peptide and nonenzymatic dipeptidase-1 (DPEP-1) inhibitor.
    LSALT peptide binds specifically to DPEP1 with no detectable binding to DPEP2 or DPEP3.
    LSALT peptide significantly reduces neutrophil recruitment to the lungs and liver and provides improved survival in models of endotoxemia.
    LSALT peptide boclks neutrophil adhesion to peritubular capillaries and reduces inflammatory monocyte recruitment to the kidney after IRI.

    Physicochemical Properties

    M.Wt 1774.14
    Formula C85H136N20O21
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    H-LSALTPSPSWLKYKAL-NH2

    References

    1. Arthur Lau, et al. Sci Adv. 2022 Feb 4;8(5):eabm0142.

    2. Choudhury S. R., et al. Cell. 178, 1205-1221.e17 (2019).

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