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Avicularin

Chemical Structure : Avicularin

CAS No.:

Avicularin

Catalog No.: PC-25357Not For Human Use, Lab Use Only.

Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1.
Avicularin alleviates acute liver failure by regulation of the TLR4/MyD88/NF-κB and Nrf2/HO-1/GPX4 pathways to reduce inflammation and ferroptosis.
Avicularin inhibits ferroptosis and improves cognitive impairments in Alzheimer's disease by modulating the NOX4/Nrf2 axis.
Avicularin induces apoptosis in NSCLC by promoting USP7-mediated degradation of FOXM1.

Physicochemical Properties

M.Wt 434.35
Formula C20H18O11
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-(((2S,3R,4R,5S)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one

References

1. Li Z, et al. Phytomedicine. 2024 Dec;135:156209.

2. Shi P, et al. J Cell Mol Med. 2023 Nov;27(21):3326-3338.

3. Du J, et al. Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug 11.

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