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Acid ceramidase inhibitor 43

Chemical Structure : Acid ceramidase inhibitor 43

CAS No.: 2907705-12-6

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Acid ceramidase inhibitor 43 (Acid Ceramidase-IN-3, aCDase-IN-3)

Catalog No.: PC-25384Not For Human Use, Lab Use Only.

Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Acid ceramidase inhibitor 43 (Acid Ceramidase-IN-3) is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell).
    Acid ceramidase inhibitor 43 promotes human hepatic stellate cells (HSCs) inactivation, as measured by a dose-dependent reduction in COL1A1 and ACTA2.
    Acid ceramidase inhibitor 43 significantly inhibited YAP/TAZ nuclear localization in HSCs.

    Physicochemical Properties

    M.Wt 443.52
    Formula C27H26FN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(4-((4-fluorobenzyl)oxy)phenyl)-N-(4-phenylbutyl)-1H-imidazole-1-carboxamide

    References

    1. Beresis R, et al. ACS Omega. 2025 Jul 31;10(31):34747-34761.

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