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Pepstatin A

Chemical Structure : Pepstatin A

CAS No.: 26305-03-3

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Pepstatin A (Pepstatin)

Catalog No.: PC-25424Not For Human Use, Lab Use Only.

Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively.

Physicochemical Properties

M.Wt 685.90
Formula C34H63N5O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6S,9S,12S,13S,17S,20S,21S)-13,21-Dihydroxy-12,20-diisobutyl-6,9-diisopropyl-2,17-dimethyl-4,7,10,15,18-pentaoxo-5,8,11,16,19-pentaazatricosan-23-oic acid

References

1. Umezawa H, et al. J Antibiot (Tokyo). 1970 May;23(5):259-62.

2. Seelmeier S, et al. Proc Natl Acad Sci U S A. 1988 Sep;85(18):6612-6.

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