MDOLL-0286 | ARH3 inhibitor | Probechem Biochemicals

Chemical Structure : MDOLL-0286

MDOLL-0286 (MDOLL0286)

Catalog No.: PC-25528Not For Human Use, Lab Use Only.

MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1.

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Biological Activity

MDOLL-0286 is a potent and selective inhibitor for ADP-ribosylhydrolase 3 (ARH3) with IC50 of 2.3 uM, selective against closely related homologues ARH1.
MDOLL-0286 inhibits ARH3's poly-ADP-ribose hydrolytic activity on cellular substrates.
MDOLL-0286 does not effectively inhibit the hydrolysis of mono-ADP-ribosylation from natural protein substrates.

Physicochemical Properties

M.Wt	299.38
Formula	C16H21N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-(1-(4-(dimethylamino)phenyl)ethylidene)hydrazineyl)-5,6-dimethylpyrimidin-4(1H)-one

References

1. Parviainen TAO, et al. ACS Chem Biol. 2025 Sep 15. doi: 10.1021/acschembio.5c00461.

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MDOLL-0286 (MDOLL0286)

Biological Activity

Physicochemical Properties

References

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