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Chemical Structure : Macrocyclic peptide D4-2
Catalog No.: PC-72498Not For Human Use, Lab Use Only.
Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM).
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Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM).
D4-2 showed a high binding affinity for the Ig-V-like domain of NOD mouse SIRPα (IgV-NOD SIRPα; KD = 8.22 nM).
D4-2 markedly promoted the phagocytosis of antibody-opsonized tumor cells by macrophages in vitro as well as enhanced the inhibitory effect of anti-CD20 or anti-gp75 antibodies on tumor formation or metastasis in vivo.
| M.Wt | 1843.05 | |
| Formula | C85H115N23O22S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daisuke Hazama, et al. Cell Chem Biol. 2020 Sep 17;27(9):1181-1191.e7.
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