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Chemical Structure : PIP4K-IN-a131
CAS No.: 2055405-95-1
Catalog No.: PC-72464Not For Human Use, Lab Use Only.
PIP4K-IN-a131 (PIP4K inhibitor a131) is a PIP4K lipid kinase inhibitor with IC50 of 1.9 uM (PI5P4Kα), selectively kills cancer cells, while protecting normal cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $558 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PIP4K-IN-a131 (PIP4K inhibitor a131) is a PIP4K lipid kinase inhibitor with IC50 of 1.9 uM (PI5P4Kα), selectively kills cancer cells, while protecting normal cells.
PIP4K-IN-a131 inhibits the kinase activity of purified PIP4K2A in vitro as well as PIP4Ks activity with IC50 of 1.9 uM and 0.6 uM, respectively.
Ras activation overrides a131-induced PIK3IP1 upregulation and activates the PI3K/Akt/mTOR pathway.
| M.Wt | 295.3 | |
| Formula | C20H13N3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-2-(1H-indol-3-yl)-3-isoquinolin-5-ylprop-2-enenitrile |
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1. Mayumi Kitagawa, et al. Nat Commun. 2017 Dec 19;8(1):2200.
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