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Chemical Structure : JumOCA peptide
Catalog No.: PC-72458Not For Human Use, Lab Use Only.
JumOCA peptide (VKELLRRKRGH) is a peptide corresponding to the OCA-B N terminus, membrane-penetrating OCA-B peptide inhibitor.
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JumOCA peptide (VKELLRRKRGH) is a peptide corresponding to the OCA-B N terminus, membrane-penetrating OCA-B peptide inhibitor.
The transcriptional coregulator OCA-B promotes expression of T cell target genes in cases of repeated antigen exposure, a necessary feature of autoimmunity.
JumOCA peptide inhibited Il2 mRNA expression relative to β-actin by 10-fold.
OCA-B inhibitor peptide reduces blood glucose and inflammatory cytokine levels in the pancreas in NOD mice with newly arisen diabetes.
JumOCA peptide treatment reduces IFN expressiondecreases CD8+ T cell autoreactivity within the PLNs, similar to genetic OCA-B deletion.
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1. Heejoo Kim, et al. J Exp Med. 2021 Mar 1; 218(3): e20200533.
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