Catalog No.: PC-72458Not For Human Use, Lab Use Only.
JumOCA peptide (VKELLRRKRGH) is a peptide corresponding to the transcriptional coregulator OCA-B N terminus, membrane-penetrating OCA-B peptide inhibitor.
JumOCA peptide (VKELLRRKRGH) is a peptide corresponding to the transcriptional coregulator OCA-B N terminus, membrane-penetrating OCA-B peptide inhibitor.
The transcriptional coregulator OCA-B promotes expression of T cell target genes in cases of repeated antigen exposure, a necessary feature of autoimmunity.
JumOCA peptide inhibited Il2 mRNA expression relative to β-actin by 10-fold.
OCA-B inhibitor peptide reduces blood glucose and inflammatory cytokine levels in the pancreas in NOD mice with newly arisen diabetes.
JumOCA peptide treatment reduces IFN expressiondecreases CD8+ T cell autoreactivity within the PLNs, similar to genetic OCA-B deletion.
Physicochemical Properties
M.Wt
1391.69
Formula
C60H110N24O14
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
Val-Lys-Glu-Leu-Leu-Arg-Arg-Lys-Arg-Gly-His
References
1. Heejoo Kim, et al. J Exp Med. 2021 Mar 1; 218(3): e20200533.
