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Chemical Structure : SGN-2FF
CAS No.: 2089647-47-0
Catalog No.: PC-73175Not For Human Use, Lab Use Only.
SGN-2FF is a potent and orally active inhibitor of glycoprotein fucosylation, directly inhibits fucosyltransferase activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SGN-2FF is a potent and orally active inhibitor of glycoprotein fucosylation, directly inhibits fucosyltransferase activity.
SGN-2FF inhibits cellular fucosylation by depletion of the fucosylation substrate GDP-fucose, as well as by direct inhibition of fucosyltransferases, leading to the production of afucosylated glycoproteins including antibodies.
SGN-2FF has antitumor activity in multiple mouse tumor models, showing substantial tumor growth delay.
SGN-2FF activates human T cells in an antigen-dependent manner, also enhanced the protective effect of a lymphoma vaccine in a syngeneic mouse model.
| M.Wt | 166.15 | |
| Formula | C6H11FO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 50 mg/mL H2O: 30 mg/mL |
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| Chemical Name/SMILES |
rel-(3S,4R,5S,6S)-3-Fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triol |
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1. Khanh T Do, et al. Oncologist. 2021 Nov;26(11):925-e1918.
2. Stephen C. Alley, et al. Cancer Res (2017) 77 (13_Supplement): DDT02-02.
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