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Chemical Structure : MCU-i11
CAS No.: 902903-59-7
Catalog No.: PC-73143Not For Human Use, Lab Use Only.
MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
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|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i11 directly binds a specific cleft in MICU1 (Kd=2.9 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i11 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.
| M.Wt | 532.615 | |
| Formula | C28H28N4O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-1(2H)-acetamide, 7-acetyl-N-(4-ethoxyphenyl)-3,4,5,6,7,8-hexahydro-2,4-dioxo-3-(phenylmethyl)- |
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1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.
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