MCU-i11

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Chemical Structure : MCU-i11

CAS No.: 902903-59-7

Catalog No.: PC-73143Not For Human Use, Lab Use Only.

MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.

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5 mg	$278	In stock
10 mg	$458	In stock
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Biological Activity

MCU-i11 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i11 directly binds a specific cleft in MICU1 (Kd=2.9 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i11 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.

Physicochemical Properties

M.Wt	532.615
Formula	C28H28N4O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Pyrido[4',3':4,5]thieno[2,3-d]pyrimidine-1(2H)-acetamide, 7-acetyl-N-(4-ethoxyphenyl)-3,4,5,6,7,8-hexahydro-2,4-dioxo-3-(phenylmethyl)-

References

1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

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MCU-i11

Biological Activity

Physicochemical Properties

References

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