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Chemical Structure : MCU-i4
CAS No.: 371924-24-2
Catalog No.: PC-73142Not For Human Use, Lab Use Only.
MCU-i4 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
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|---|---|---|---|
| 25 mg | $128 | In stock | |
| 100 mg | $358 | In stock | |
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| 1 g | Get quote |
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MCU-i4 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i4 directly binds a specific cleft in MICU1 (Kd=8.4 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i4 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.
| M.Wt | 377.49 | |
| Formula | C23H27N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate |
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1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.
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