MCU-i4

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Chemical Structure : MCU-i4

CAS No.: 371924-24-2

Catalog No.: PC-73142Not For Human Use, Lab Use Only.

MCU-i4 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.

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100 mg	$358	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

MCU-i4 is a specific MICU1 targeting compound that negative modulate mitochondrial Ca2+ uptake.
MCU-i4 directly binds a specific cleft in MICU1 (Kd=8.4 uM), a key element of the mitochondrial calcium uniporter (MCU) complex that controls channel gating.
MCU-i4 effectively inhibited mitochondrial Ca2+ uptake at 5 uM, impair muscle cell growth.

Physicochemical Properties

M.Wt	377.49
Formula	C23H27N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate

References

1. Giulia Di Marco, et al. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6.

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MCU-i4

Biological Activity

Physicochemical Properties

References

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