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SST0872AA1

Chemical Structure : SST0872AA1

CAS No.: 2245200-10-4

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SST0872AA1 (SST 0872AA1)

Catalog No.: PC-73270Not For Human Use, Lab Use Only.

SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SST0872AA1 is a potent, small molecule Heparanase (Hpse) inhibitor with IC50 of 0.08 uM.
    SST0872AA1 inhibits the invasive ability of human CME-1 synovial sarcoma cells, does not affect cell proliferation.
    SST0872AA1 decreases the mRNA levels of genes encoding for proangiogenic factors, such as FGF1/2, VEGF, and MMP-9, and for Hpse (HPSE-1).

    Physicochemical Properties

    M.Wt 728.684
    Formula C35H26F2N6O8S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,2'-((2,2'-(((Thiocarbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(benzo[d]oxazole-2,5-diyl))bis(acetyl))bis(azanediyl))diacetic Acid

    References

    1. Antonella Messore, et al. J Med Chem. 2018 Dec 13;61(23):10834-10859.

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