Catalog No.: PC-73217Not For Human Use, Lab Use Only.
Ceapin-A7 is a selective inhibitor of ATF6α with IC50 of 0.59 uM, selective over ATF6β, PERK and other branches of the unfolded protein response (UPR).
Ceapin-A7 is a selective inhibitor of ATF6α with IC50 of 0.59 uM, selective over ATF6β, PERK and other branches of the unfolded protein response (UPR).
Ceapin-A7 inhibits ER stress-induced upregulation of BiP in vitro.
Ceapin-A7 inhibits cleavage and functional activation of endogenous ATF6 in response to ER stress in vitro.
Ceapin-A7 could phenocopy the results obtained using genetic ablation of ATF6α in mouse models.
Ceapin-A7 is a first-in-class series of ATF6α inhibitors that selectively blocks ATF6α and not ATF6β, SREBP or other UPR branches.
