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Chemical Structure : DLin-MC3-DMA
CAS No.: 1224606-06-7
Catalog No.: PC-73149Not For Human Use, Lab Use Only.
DLin-MC3-DMA is an ionizable amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $478 | In stock | |
| 100 mg | $758 | In stock | |
| 250 mg | Get quote |
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DLin-MC3-DMA is an ionizable amino lipid (apparent pKa = 6.44) that has been used in combination with other lipids in the formation of lipid nanoparticles.
Administration of Factor VII siRNA in DLin-MC3-DMA-containing lipid nanoparticles reduces plasma Factor VII protein levels in mice.
Formulations containing DLin-MC3-DMA have been used in the development of lipid nanoparticles for siRNA delivery in patients with hereditary transthyretin-mediated amyloidosis.
| M.Wt | 642.1 | |
| Formula | C43H79NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
100 mM in Ethanol (64.2 mg/mL) |
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| Chemical Name/SMILES |
(6Z,9Z,28Z,31Z)-Heptatriaconta-6,9,28,31-tetraen-19-yl 4-(dimethylamino)butanoate |
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1. Kulkarni JA, et al. Nanomedicine. 2017 May;13(4):1377-1387.
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