ARN14494 (ARN-14494) is a potent, small molecule serine palmitoyltransferase (SPT) inhibitor with IC50 of 27.3 nM.
ARN14494 prevents the synthesis of pro-inflammatory cytokines TNFα and IL1β, growth factor TGFβ1, and oxidative stress-related enzymes iNOS and COX2 in mouse primary cortical astrocytes.
ARN14494 also exerts neuroprotective properties in primary cortical neurons.
ARN14494 inhibits the synthesis of long-chain ceramides and dihydroceramides that are involved in AD progression, promotes neuronal survival after astrocyte amyloid beta 1-42 injury.
