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NCGC00135472

Chemical Structure : NCGC00135472

CAS No.: 862811-76-5

NCGC00135472 (DRV1 (GPR32) agonist C2A)

Catalog No.: PC-35891Not For Human Use, Lab Use Only.

DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively.

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    Biological Activity

    DRV1 (GPR32) agonist C2A (NCGC00135472) is a synthetic molecule that activate human resolvin D1 receptor DRV1/GPR32 receptor with EC50 of 0.37 uM and 0.05 uM in β-arrestin and cAMP assays, respectively.
    DRV1 (GPR32) agonist C2A (NCGC00135472) elicits rapid impedance changes in cells overexpressing recombinant DRV1, stimulates phagocytosis of serum-treated zymosan at concentrations comparable with that of RvD1, the endogenous DRV1 ligand, in human macrophages.
    DRV1 (GPR32) agonist C2A (NCGC00135472) also significantly increases by these chemotypes in DRV1-transfected macrophages in live E. coli.

    Physicochemical Properties

    M.Wt 364.356
    Formula C20H14F2N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3,4-difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]benzamide

    References

    1. Chiang N, et al. Cell Chem Biol. 2018 Nov 19. pii: S2451-9456(18)30383-0.

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