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S29434

Chemical Structure : S29434

CAS No.: 874484-20-5

S29434 (S 29434;S-29434)

Catalog No.: PC-35919Not For Human Use, Lab Use Only.

S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
S29434 inhibits QR2-mediated ROS production within the 100 nM range in various cell types, including hepatoma HepG2 cells, the astroglial cell line U373 and primary dopaminergic neurons.
S29434 (S 29434) is fairly stable in vivo.

Physicochemical Properties

M.Wt 374.4
Formula C21H18N4O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide

References

1. Boutin JA, et al. Mol Pharmacol. 2018 Dec 19. pii: mol.118.114231. doi: 10.1124/mol.118.114231.

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