Catalog No.: PC-35895Not For Human Use, Lab Use Only.
PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM.
PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of <40 nM against all mammalian species LOXL2, inhibits human LOXL3 with IC50 of 63 nM.
PXS-5153A displays >40-fold selectivity for LOXL2 over both LOX and LOXL1 and >700-fold over other related amine oxidases.
PXS-5153A dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro.
PXS-5153A reduced disease severity and improved liver function by diminishing collagen content and collagen crosslinks in carbon tetrachloride or streptozotocin/high fat diet-induced liver fibrosis models.
