SH514 | IRF4 inhibitor | Probechem Biochemicals

Chemical Structure : SH514

SH514 (SH-514)

Catalog No.: PC-23762Not For Human Use, Lab Use Only.

Packing	Price	Stock	Quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

SH514 is a specific small molecule inhibitor of interferon regulatory factor 4 (IRF4) with IC50 of 2.63 uM, inhibits proliferation of IRF4-high-expressing NCI-H929 and MM.1R MM cells with IC50 of 0.08 uM and 0.11 uM, respectively.
SH514 binds to the IRF4-DBD domain with SPR KD of 1.28 uM.
SH514 shows no effect on the stability of IRF3.
SH514 selectively inhibits proliferation of IRF4-high-expressing cells, regulates IRF4 downstream gene expression, inhibits the protein expression of CDC2, Cyclin B1, Cyclin D1, Cyclin E1, and CMYC.
SH514 (12.5-25 mg/kg once daily) effectively inhibits MM tumor growth in NCI–H929 subcutaneous tumor model.

Physicochemical Properties

M.Wt	514.67
Formula	C32H38N2O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-((8S,9S,10S,13S,14S,17R)-2-cyano-4,4,10,13-tetramethyl-3,7-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-N-(4-methoxyphenyl)propanamide

References

1. Zhang JZ, et al. Eur J Med Chem. 2025 Jan 6;285:117240.

SH514 (SH-514)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.