LZX-2-73

Chemical Structure : LZX-2-73

Catalog No.: PC-23558Not For Human Use, Lab Use Only.

LZX-2-73 is a specific and effective NUPR1 inhibitor with Kd of 2.7 uM, inhibits MIA PaCa-2 cell proliferation with IC50 of 10.9 uM.

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Biological Activity

LZX-2-73 is a specific and effective NUPR1 inhibitor with Kd of 2.7 uM, inhibits MIA PaCa-2 cell proliferation with IC50 of 10.9 uM.
LZX-2-73 is more efficient than AJO14 in vitro and in vivo.
5 or 25 mg/kg of LZX-2-73 showed slow tumor growth and a significantly reduced tumor volume compared to the control group in a dose-dependent manner.
LZX-2-73 does not bind to hERG, indicating no risk of cardiotoxicity.

Physicochemical Properties

M.Wt	427.33
Formula	C16H15BrN2O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-bromophenyl)-3-(3-(methylsulfonyl)-6,7-dihydrobenzo[c]thiophen-1-yl)urea

References

1. Liu X, et al. Sci Rep. 2024 Nov 27;14(1):29515.

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LZX-2-73

Biological Activity

Physicochemical Properties

References

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