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Chemical Structure : DFMO
Catalog No.: PC-36049Not For Human Use, Lab Use Only.
DFMO (Ornithine Decarboxylase inhibitor DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.
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DFMO (Ornithine Decarboxylase inhibitor DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.
DFMO displays antiapoptotic, antiangiogenic and antiparasitic activity, synergistically reduces cell viability in NB cells when combined with AMXT-1501, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.
| M.Wt | 182.171 | |
| Formula | C6H12F2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.
2. Wu Y, et al. Biochem J. 2012 Mar 15;442(3):693-701.
3. Carrillo C, et al. Biochem Biophys Res Commun. 2000 Dec 20;279(2):663-8.
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