DFMO (MDL71782, RMI71782, α-difluoromethylornithine, Eflornithine) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.
DFMO displays antiapoptotic, antiangiogenic and antiparasitic activity, synergistically reduces cell viability in NB cells when combined with AMXT-1501, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.
Physicochemical Properties
M.Wt
182.171
Formula
C6H12F2N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2,5-diamino-2-(difluoromethyl)pentanoic acid
References
1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.
2. Wu Y, et al. Biochem J. 2012 Mar 15;442(3):693-701.
3. Carrillo C, et al. Biochem Biophys Res Commun. 2000 Dec 20;279(2):663-8.
