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DFMO

Chemical Structure : DFMO

CAS No.: 68278-23-9

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DFMO (Ornithine Decarboxylase inhibitor DFMO)

Catalog No.: PC-36049Not For Human Use, Lab Use Only.

DFMO (Ornithine Decarboxylase inhibitor DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

DFMO (Ornithine Decarboxylase inhibitor DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.
DFMO displays antiapoptotic, antiangiogenic and antiparasitic activity, synergistically reduces cell viability in NB cells when combined with AMXT-1501, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.

Physicochemical Properties

M.Wt 182.171
Formula C6H12F2N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,5-diamino-2-(difluoromethyl)pentanoic acid

References

1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.

2. Wu Y, et al. Biochem J. 2012 Mar 15;442(3):693-701.

3. Carrillo C, et al. Biochem Biophys Res Commun. 2000 Dec 20;279(2):663-8.

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