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PIN1 inhibitor VS10

Chemical Structure : PIN1 inhibitor VS10

CAS No.: 920849-78-1

PIN1 inhibitor VS10 (VS10)

Catalog No.: PC-36053Not For Human Use, Lab Use Only.

PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM.

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    Biological Activity

    PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM.
    VS10 displays >2-fold more potency than ATRA; reduces cancer cell viability of ovarian cancer cell lines with IC50 of 53.9-76.4 uM.
    VS10 targets PIN1 to the proteasome, and induces PIN1 protein degradation in NIH3T3 fibroblasts, also shows inhibitory effects on PIN1 target proteins (cyclin D1, pSer473-Akt and β-catenin) in the OVCAR3 cell line.

    Physicochemical Properties

    M.Wt 377.414
    Formula C21H15NO4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(3-methylbenzofuran-2-carboxamido)-5-phenylthiophene-2-carboxylic acid

    References

    1. Russo Spena C, et al. J Cell Physiol. 2019 Jan 29. doi: 10.1002/jcp.28224.

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