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Chemical Structure : CCI-006
CAS No.: 292053-42-0
Catalog No.: PC-36024Not For Human Use, Lab Use Only.
CCI-006 (CCI 006) is a small molecule that inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization, and selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells (MLL-r).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $398 | In stock | |
| 50 mg | $588 | In stock | |
| 100 mg | Get quote |
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CCI-006 (CCI 006) is a small molecule that inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization, and selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells (MLL-r).
CCI-006 inhibited mitochondrial respiration and induced mitochondrial membrane depolarization and apoptosis in a subset (7/11, 64%) of MLL-rearranged leukemia cell lines.
Silencing of HIF1α expression sensitized an intrinsically unresponsive MLL-rearranged leukemia cell to CCI-006, indicating that HIF1α pathway plays a role in determining sensitivity to CCI-006.
Unresponsive MLL-rearranged leukemia cells expressed increased levels of MEIS1.
CCI-006 is a novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulnerability in a subset of low HIF1α/low MEIS1-expressing MLL-rearranged leukemia cells.
| M.Wt | 332.33 | |
| Formula | C15H12N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methyl-2-cyano-3-(5-(4-sulfamoylphenyl)furan-2-yl)acrylate |
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1. Klaartje Somers, et al. Oncogene (2019).
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