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CCI-006

Chemical Structure : CCI-006

CAS No.: 292053-42-0

CCI-006 (CCI006, CCI 006)

Catalog No.: PC-36024Not For Human Use, Lab Use Only.

CCI-006 (CCI 006) is a small molecule that inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization, and selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells (MLL-r).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CCI-006 (CCI 006) is a small molecule that inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization, and selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells (MLL-r).
CCI-006 inhibited mitochondrial respiration and induced mitochondrial membrane depolarization and apoptosis in a subset (7/11, 64%) of MLL-rearranged leukemia cell lines.
Silencing of HIF1α expression sensitized an intrinsically unresponsive MLL-rearranged leukemia cell to CCI-006, indicating that HIF1α pathway plays a role in determining sensitivity to CCI-006.
Unresponsive MLL-rearranged leukemia cells expressed increased levels of MEIS1.
CCI-006 is a novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulnerability in a subset of low HIF1α/low MEIS1-expressing MLL-rearranged leukemia cells.

Physicochemical Properties

M.Wt 332.33
Formula C15H12N2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Methyl-2-cyano-3-(5-(4-sulfamoylphenyl)furan-2-yl)acrylate

References

1. Klaartje Somers, et al. Oncogene (2019).

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