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Pyrazinib

Chemical Structure : Pyrazinib

CAS No.: 200417-97-6

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Pyrazinib (Pyrazinib P3, Pyrazinib (P3))

Catalog No.: PC-36026Not For Human Use, Lab Use Only.

Pyrazinib (Pyrazinib (P3)) is a pyrazine phenol small molecule drug with anti-angiogenic and anti-metabolic activity in-vivo in zebrafish and in-vitro isogenic models of OAC radioresistance.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pyrazinib (Pyrazinib (P3)) is a pyrazine phenol small molecule drug with anti-angiogenic and anti-metabolic activity in-vivo in zebrafish and in-vitro isogenic models of OAC radioresistance.
    Pyrazinib significantly inhibited blood vessel development in zebrafish, significantly reduced measures of oxidative phosphorylation and glycolysis in isogenic model of OAC radioresistance.
    Pyrazinib is a novel therapeutic radiosensitiser in Oesophageal adenocarcinoma (OAC).

    Physicochemical Properties

    M.Wt 198.225
    Formula C12H10N2O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-(2-Pyrazin-2-yl-vinyl)-phenol

    References

    1. Buckley AM, et al. Cancer Lett. 2019 Jan 18. pii: S0304-3835(19)30021-7.

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