Catalog No.: PC-36048Not For Human Use, Lab Use Only.
AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO.
AMXT-1501 tetrahydrochloride (AMXT 1501, AMXT1501) is a novel potent polyamine transport inhibitor, synergistically reduces cell viability in NB cells in combination with DFMO.
AMXT-1501 tetrahydrochloride completely blocked radiolabeled spermidine uptake in multiple NB cell lines, whereas the combination of AMXT 1501 and DFMO was synergistic in reducing colony formation in BE(2)-C and KELLY cells.
AMXT-1501 tetrahydrochloride exhibits growth inhibition via G1 cell cycle arrest in NB cells;.
AMXT-1501 tetrahydrochloride inhibits polyamine synthesis and uptake, reduces tumor progression and prolongs survival in mouse models of neuroblastoma combined with DFMO.
Physicochemical Properties
M.Wt
714.768
Formula
C32H72Cl4N6O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(5-amino-6-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-6-oxohexyl)palmitamide tetrahydrochloride salt
References
1. Gamble LD, et al. Sci Transl Med. 2019 Jan 30;11(477). pii: eaau1099. doi: 10.1126/scitranslmed.aau1099.
2. Samal K, et al. Int J Cancer. 2013 Sep 15;133(6):1323-33.
3. Hayes CS, et al. Cancer Immunol Res. 2014 Mar;2(3):274-85.
4. Murray-Stewart TR, et al. Biochem J. 2016 Oct 1;473(19):2937-53.
