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AER-271

Chemical Structure : AER-271

CAS No.: 634913-39-6

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AER-271 (AER271)

Catalog No.: PC-36073Not For Human Use, Lab Use Only.

AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility.

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10 mg $98 In stock
25 mg $158 In stock
50 mg $258 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AER-271 (AER271) is a selective, small molecule inhibitor of aquaporin-4 (AQP4), the prodrug of AER-270 with enhanced solubility.
AER-271 shows improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema.

Physicochemical Properties

M.Wt 463.653
Formula C15H9ClF6NO5P
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate

References

1. Farr GW, et al. Neuroscience. 2019 Feb 6. pii: S0306-4522(19)30054-5.

2. Wallisch JS, et al. Pediatr Res. 2018 Oct 26. doi: 10.1038/s41390-018-0215-5.

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