T-690 | Glucosylceramide synthase inhibitor

Chemical Structure : T-690

T-690 (T690)

Catalog No.: PC-38114Not For Human Use, Lab Use Only.

T-690 is a potent, selective, oral inhibitor of glucosylceramide synthase (GCS) with IC50 of 15 nM.

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Biological Activity

T-690 is a potent, selective, oral inhibitor of glucosylceramide synthase (GCS) with IC50 of 15 nM.
T-690 has no SERT inhibitory activity, does not affect GCase activity (EC50>300 uM),shows no strong CYP inhibition and good in vitro metabolic stability.
T-690 reduces GlcCer levels with strong potency (EC50=4.4 nM) in cellular assays.
T-690 (30, 100, and 300 mg/kg) reduced GlcCer concentrations in the plasma and cerebral cortex in a dose-dependent manner following T-690 administration in mice, shows 12.7 times stronger potency against human GCS than mouse GCS.

Physicochemical Properties

M.Wt	447.414
Formula	C22H20F3N3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-(2-Hydroxypropan-2-yl)phenyl]-3-oxo-2-[2-(2,2,2-trifluoroethoxy)phenyl]-2,3-dihydropyridazine-4-carboxamide

References

1. Tanaka Y, et al. J Med Chem. 2022 Mar 10;65(5):4270-4290.

T-690 (T690)

Biological Activity

Physicochemical Properties

References

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