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Chemical Structure : T-690
Catalog No.: PC-38114Not For Human Use, Lab Use Only.
T-690 is a potent, selective, oral inhibitor of glucosylceramide synthase (GCS) with IC50 of 15 nM.
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T-690 is a potent, selective, oral inhibitor of glucosylceramide synthase (GCS) with IC50 of 15 nM.
T-690 has no SERT inhibitory activity, does not affect GCase activity (EC50>300 uM),shows no strong CYP inhibition and good in vitro metabolic stability.
T-690 reduces GlcCer levels with strong potency (EC50=4.4 nM) in cellular assays.
T-690 (30, 100, and 300 mg/kg) reduced GlcCer concentrations in the plasma and cerebral cortex in a dose-dependent manner following T-690 administration in mice, shows 12.7 times stronger potency against human GCS than mouse GCS.
| M.Wt | 447.414 | |
| Formula | C22H20F3N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tanaka Y, et al. J Med Chem. 2022 Mar 10;65(5):4270-4290.
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