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Chemical Structure : PXS-5120A
CAS No.: 2125955-70-4
Catalog No.: PC-38097Not For Human Use, Lab Use Only.
PXS-5120A is a potent, selective, irreversible inhibitor of Lysyl oxidase-like 2 (LOXL2) with IC50 of 5 and 6 nM (hLOXL2 and mLOXL2).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $248 | In stock | |
| 5 mg | $428 | In stock | |
| 10 mg | $698 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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PXS-5120A is a potent, selective, irreversible inhibitor of Lysyl oxidase-like 2 (LOXL2) with IC50 of 5 and 6 nM (hLOXL2 and mLOXL2).
PXS-5120A is >300-fold selective for LOXL2 over LOX (pIC50=5.8), shows negligible substrate activity in vitro for related amine oxidase family members.
PXS-5120A also shows potent inhibition of LOXL3 (IC50=16 nM).
PXS-5120A inhibits the crosslinking of rat collagen in vitro with IC50 of 13 nM.
| M.Wt | 481.967 | |
| Formula | C22H25ClFN3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(Z)-1-(4-Amino-2-fluorobut-2-en-1-yl)-3-(3-(N,N-dimethylsulfamoyl)phenyl)-2-methyl-1H-indole-5-carboxylic Acid Hydrochloride |
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1. Findlay AD, et al. J Med Chem. 2019 Nov 14;62(21):9874-9889.
2. Setargew YFI, et al. Cancers (Basel). 2021 Jan 27;13(3):491.
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