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RA5557

Chemical Structure : RA5557

CAS No.: 2414352-73-9

RA5557 (RA-5557)

Catalog No.: PC-38105Not For Human Use, Lab Use Only.

RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RA 5557 is a brain-penetrant, selective, oral UGT8 inhibitor, inhibits galactosylceramide biosynthesis.
    RA 5557 reduced pathologically elevated psychosine concentrations (72-86%) in the midbrain and cerebral cortex in twitcher mice.
    RA 5557 decreased galactosylceramides by about 70% in midbrain and cerebral cortex in mutant and wild type animals.
    RA 5557 significantly decreased several characteristic inflammatory response markers without causing apparent toxicity to myelin-producing cells in wild type and mutant mice.
    RA 5557 decreases in vivo galactosphingolipid biosynthesis in murine Krabbe disease.

    Physicochemical Properties

    M.Wt 529.454
    Formula C20H21F6N3O5S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(trifluoromethoxy)ethyl (2R,4R)-2-methyl-4-((3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)oxy)piperidine-1-carboxylate

    References

    1. Eva Zaccariotto, et al. Biomed Pharmacother. 2022 Mar 12;149:112808.

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