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Chemical Structure : Transthyretin stabilizer M-23
Catalog No.: PC-49422Not For Human Use, Lab Use Only.
Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.
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Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.
M-23 effectively prevented TTR amyloid formation at acidic pH, stabilizes the TTR dimer-dimer interface.
M-23 strongly binds to TTR in human plasma, exhibiting a higher TTR stabilizing activity than the reference molecule tolcapone.
| M.Wt | 293.206 | |
| Formula | C13H8FNO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pinheiro F, et al. J Med Chem. 2022 Oct 28. doi: 10.1021/acs.jmedchem.2c01195.
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