Transthyretin stabilizer M-23

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Chemical Structure : Transthyretin stabilizer M-23

Catalog No.: PC-49422Not For Human Use, Lab Use Only.

Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.

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Biological Activity

Transthyretin stabilizer M-23 is a potent transthyretin (TTR) stabilizer with binding Kd of 6 nM (WT-TTR), enhances TTR tetramer stability both in vitro and in whole serume.
M-23 effectively prevented TTR amyloid formation at acidic pH, stabilizes the TTR dimer-dimer interface.
M-23 strongly binds to TTR in human plasma, exhibiting a higher TTR stabilizing activity than the reference molecule tolcapone.

Physicochemical Properties

M.Wt	293.206
Formula	C13H8FNO6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(3,4-Dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone

References

1. Pinheiro F, et al. J Med Chem. 2022 Oct 28. doi: 10.1021/acs.jmedchem.2c01195.

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