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Chemical Structure : KIO-100
Catalog No.: PC-49419Not For Human Use, Lab Use Only.
KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM).
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KIO-100 (PP-001) is a novel potent, specific small molecule inhibitor of DHODH with IC50 of <4 nM, 150-fold higher potency than leflunomide (IC50 of 650 nM).
KIO-100 (PP-001) does not inhibit tyrosine kinase or cause hepatotoxicity like leflunomide since, like other small molecule DHODH inhibitors, KIO-100 (PP-001) does not need to be converted from a prodrug to its active form in the liver.
KIO-100 (PP-001) reduces the proliferation in a dose-dependent manner in human peripheral blood lymphocytes (PBL), also inhibits cytokine/chemokine secretion of human lymphocytes.
KIO-100 (PP-001) efficiently suppresses rat uveitis in a preventive as well as therapeutic mode.
| M.Wt | 479.325 | |
| Formula | C19H8F7NO4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Diedrichs-Möhring M, et al. J Neuroinflammation. 2018 Feb 21;15(1):54.
2. Thurau S, et al. Front Med (Lausanne). 2022 Oct 17;9:1023224.
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