Catalog No.: PC-49404Not For Human Use, Lab Use Only.
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.
SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.
SMC-21598 does not inhibit TGF-β, CXCL12, and EGF -induced cell migration.
SMC-21598 inhibited CCL18 induced cell migration in a concentration dependent manner with IC50 value of 130±70 nM for MDA-MB-231 cells.
SMC-21598 (10 uM) significantly inhibited CCL18-induced breast cancer cells adherence, invasiveness, and migration.
SMC-21598 did not significantly affect xenografts growth, but inhibited lung metastasis.
