RBS-10 | NQO1 inhibitor | Probechem Biochemicals

Chemical Structure : RBS-10

RBS-10 (RBS10)

Catalog No.: PC-21628Not For Human Use, Lab Use Only.

RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.

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Biological Activity

RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.
RBS-10 inhibits the enzymatic activity of NQO1, againin intact cells and in vitro.
RBS-10 metabolism induces apoptosis via ROS and DNA damage in an NQO1-dependent manner and this bioactivation is indispensable for the cytotoxic outcome.

Physicochemical Properties

M.Wt	365.35
Formula	C19H15N3O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-methylbenzamido)phenyl)-5-nitrofuran-2-carboxamide

References

1. Barbosa BM, et al. Angew Chem Int Ed Engl. 2023 Dec 28:e202316730.

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RBS-10 (RBS10)

Biological Activity

Physicochemical Properties

References

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