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RBS-10

Chemical Structure : RBS-10

CAS No.: 352341-77-6

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RBS-10 (RBS10)

Catalog No.: PC-21628Not For Human Use, Lab Use Only.

RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.
    RBS-10 inhibits the enzymatic activity of NQO1, againin intact cells and in vitro.
    RBS-10 metabolism induces apoptosis via ROS and DNA damage in an NQO1-dependent manner and this bioactivation is indispensable for the cytotoxic outcome.

    Physicochemical Properties

    M.Wt 365.35
    Formula C19H15N3O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-(3-methylbenzamido)phenyl)-5-nitrofuran-2-carboxamide

    References

    1. Barbosa BM, et al. Angew Chem Int Ed Engl. 2023 Dec 28:e202316730.

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