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Chemical Structure : RBS-10
Catalog No.: PC-21628Not For Human Use, Lab Use Only.
RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.
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RBS-10 is a small molecule that shows preferential cytotoxicity against cells pan-resistant to degraders, acts as a prodrug bioactivated by the oxidoreductase enzyme NQO1.
RBS-10 inhibits the enzymatic activity of NQO1, againin intact cells and in vitro.
RBS-10 metabolism induces apoptosis via ROS and DNA damage in an NQO1-dependent manner and this bioactivation is indispensable for the cytotoxic outcome.
| M.Wt | 365.35 | |
| Formula | C19H15N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Barbosa BM, et al. Angew Chem Int Ed Engl. 2023 Dec 28:e202316730.
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