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AD-8007

Chemical Structure : AD-8007

CAS No.: 1497439-74-3

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AD-8007 (AD8007)

Catalog No.: PC-21664Not For Human Use, Lab Use Only.

AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-8007 specifically binds ACSS2 (KD=126 uM) but not the mitochondrial isoform hACSS1.
AD-8007 leads to a significant reduction in lipid storage, reduction in colony formation, and increase in cell death in MDA-MB-231BR cells.
AD-8007 significantly reduces tumor size and synergizes with radiation in blocking BCBM tumor growth in an ex vivo orthotopic brain-slice tumor model.

Physicochemical Properties

M.Wt 334.46
Formula C22H26N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-amino-2-cyclopropyl-1-(3,3-diphenylpiperidin-1-yl)ethan-1-one

References

1. Emily Esquea, et al. bioRxiv. December 23, 2023

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