Catalog No.: PC-21664Not For Human Use, Lab Use Only.
AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 0.89 uM, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-8007 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 0.89 uM, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-8007 specifically binds ACSS2 (KD=126 uM) but not the mitochondrial isoform hACSS1.
AD-8007 leads to a significant reduction in lipid storage, reduction in colony formation, and increase in cell death in MDA-MB-231BR cells.
AD-8007 significantly reduces tumor size and synergizes with radiation in blocking BCBM tumor growth in an ex vivo orthotopic brain-slice tumor model.
