Catalog No.: PC-21663Not For Human Use, Lab Use Only.
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 0.86 uM, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor with IC50 of 0.86 uM, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-5584 specifically binds ACSS2 (KD=188 uM) but not the mitochondrial isoform hACSS1.
AD-5584 leads to a significant reduction in lipid storage, reduction in colony formation, and increase in cell death in MDA-MB-231BR cells.
AD-5584 significantly reduces tumor size and synergizes with radiation in blocking BCBM tumor growth in an ex vivo orthotopic brain-slice tumor model.
