Chemical Structure : AD-5584
CAS No.:
2306525-79-9
AD-5584
(AD5584)
Catalog No.: PC-21663Not For Human Use, Lab Use Only.
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AD-5584 is a potent, brain permeable human Acetyl-CoA synthetase 2 (ACSS2) inhibitor, a key metabolic enzyme involved in regulating fatty acid synthesis and protein acetylation in tumor cells.
AD-5584 specifically binds ACSS2 (KD=188 uM) but not the mitochondrial isoform hACSS1.
AD-5584 leads to a significant reduction in lipid storage, reduction in colony formation, and increase in cell death in MDA-MB-231BR cells.
AD-5584 significantly reduces tumor size and synergizes with radiation in blocking BCBM tumor growth in an ex vivo orthotopic brain-slice tumor model.
Physicochemical Properties
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M.Wt
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414.91
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Formula
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C22H24ClFN4O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-((5-chloro-1H-benzo[d]imidazol-2-yl)methyl)-2-(4-fluorophenyl)-N-methyl-2-(piperidin-1-yl)acetamide
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References
1. Emily Esquea, et al. bioRxiv. December 23, 2023
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