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Chemical Structure : PF-9366
CAS No.: 72882-78-1
Catalog No.: PC-62311Not For Human Use, Lab Use Only.
PF-9366 is a novel selective, allosteric methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM, Kd of 170 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $298 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | Get quote |
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PF-9366 is a novel selective, allosteric methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM, Kd of 170 nM.
PF-9366 shows no substantial off-target activity in a functional panel of representative GPCRs, neurotransporters, phosphodiesterases, and ion channels;.
PF-9366 inhibits cellular SAM production with an IC50 of 255 nM in Huh-7 cells.
| M.Wt | 350.85 | |
| Formula | C20H19ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
7-Chloro-N,N-dimethyl-5-phenyl[1,2,4]triazolo[4,3-a]quinoline-1-ethanamine |
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1. Quinlan CL, et al. Nat Chem Biol. 2017 Jul;13(7):785-792.
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