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Chemical Structure : Deoxynyboquinone
Catalog No.: PC-62343Not For Human Use, Lab Use Only.
Deoxynyboquinone (NSC 165572, DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1).
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Deoxynyboquinone (NSC 165572, DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1).
Deoxynyboquinone's lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS).
| M.Wt | 284.271 | |
| Formula | C15H12N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Bair JS, et al. J Am Chem Soc. 2010 Apr 21;132(15):5469-78.
2. Huang X, et al. Cancer Res. 2012 Jun 15;72(12):3038-47.
3. Lee HY, et al. ACS Chem Biol. 2017 May 19;12(5):1416-1424.
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