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Deoxynyboquinone

Chemical Structure : Deoxynyboquinone

CAS No.: 96748-86-6

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Deoxynyboquinone (NSC 165572, DNQ)

Catalog No.: PC-62343Not For Human Use, Lab Use Only.

Deoxynyboquinone (NSC 165572, DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1).

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    Biological Activity

    Deoxynyboquinone (NSC 165572, DNQ) is a potent inducer of cancer cell death that induces death of cancer cells in culture with IC50 of 16-210 nM, a substrate for NAD(P)H:quinone oxidoreductase (NQO1).
    Deoxynyboquinone's lethality relies on NQO1-dependent futile redox cycling that consumes oxygen and generates extensive reactive oxygen species (ROS).

    Physicochemical Properties

    M.Wt 284.271
    Formula C15H12N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,4,6-Trimethylpyrido[3,2-g]quinoline-2,5,8,10(1H,9H)-tetrone

    References

    1. Bair JS, et al. J Am Chem Soc. 2010 Apr 21;132(15):5469-78.

    2. Huang X, et al. Cancer Res. 2012 Jun 15;72(12):3038-47.

    3. Lee HY, et al. ACS Chem Biol. 2017 May 19;12(5):1416-1424.

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