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Chemical Structure : Inflachromene
CAS No.: 908568-01-4
Catalog No.: PC-62259Not For Human Use, Lab Use Only.
Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.
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|---|---|---|---|
| 5 mg | $278 | In stock | |
| 10 mg | $458 | In stock | |
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Inflachromene (ICM) is a microglial inhibitor with anti-inflammatory effects, directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.
Inflachromene blocks the sequential processes of cytoplasmic localization and extracellular release of HMGBs by perturbing its post-translational modification.
Inflachromene effectively downregulates proinflammatory functions of HMGB and reduces neuronal damage in vivo.
| M.Wt | 377.4 | |
| Formula | C21H19N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5,12b-dihydro-10-hydroxy-7,7-dimethyl-2-phenyl-1H,7H-[1]benzopyrano[4,3-c][1,2,4]triazolo[1,2-a]pyridazine-1,3(2H)-dione |
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1. Lee S, et al. Nat Chem Biol. 2014 Dec;10(12):1055-60.
2. Cho W, et al. J Med Chem. 2017 Jan 12;60(1):170-179.
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