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Chemical Structure : CCG-203971
CAS No.: 1443437-74-8
Catalog No.: PC-62825Not For Human Use, Lab Use Only.
CCG-203971(CCG203971) is a potent Rho/MKL1/SRF transcriptional pathway inhibitor, suppresses PC-3 cell migration in scratch wound assays (IC50=4.2 uM), blocks nuclear localization and activity of MRTF-A in SK-Mel-147 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote | ||
| 250 mg | Get quote |
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CCG-203971 (CCG203971) is a potent Rho/MKL1/SRF transcriptional pathway inhibitor, suppresses PC-3 cell migration in scratch wound assays (IC50=4.2 uM), blocks nuclear localization and activity of MRTF-A in SK-Mel-147 cells.
CCG-203971 selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts.
CCG-203971 inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts.
CCG-203971 prevents bleomycin-induced skin thickening and collagen deposition in vivo.
| M.Wt | 408.88 | |
| Formula | C23H21ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide |
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1. Bell JL, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3826-32.
2. Haak AJ, et al. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6.
3. Haak AJ, et al. Mol Cancer Ther. 2017 Jan;16(1):193-204.
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