Catalog No.: PC-62825Not For Human Use, Lab Use Only.
CCG-203971(CCG203971) is a potent Rho/MKL1/SRF transcriptional pathway inhibitor, suppresses PC-3 cell migration in scratch wound assays (IC50=4.2 uM), blocks nuclear localization and activity of MRTF-A in SK-Mel-147 cells.
CCG-203971 (CCG203971) is a potent Rho/MKL1/SRF transcriptional pathway inhibitor, suppresses PC-3 cell migration in scratch wound assays (IC50=4.2 uM), blocks nuclear localization and activity of MRTF-A in SK-Mel-147 cells.
CCG-203971 selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts.
CCG-203971 inhibits expression of CTGF, α-SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGFβ-stimulated fibroblasts.
CCG-203971 prevents bleomycin-induced skin thickening and collagen deposition in vivo.
