Chemical Structure : ML352
Catalog No.: PC-62785Not For Human Use, Lab Use Only.
ML352 (VU-0476201) is a potent, selective choline transporter (CHT) inhibitor with Ki of 92 nM.
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ML352 (VU-0476201) is a potent, selective choline transporter (CHT) inhibitor with Ki of 92 nM; exhibits no inhibition on AChE, ChAT, and dopamine, serotonin, norepinephrine transporters; exhibits noncompetitive choline uptake inhibition in intact cells and synaptosomes , and reduces the apparent density of HC-3 binding sites in membrane assay; shows limited in vitro metabolism and significant CNS penetration.
M.Wt | 387.47 | |
Formula | C21H29N3O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Ennis EA, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):417-27.
2. Bertron JL, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-40.
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