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DB2115

Chemical Structure : DB2115

CAS No.: 1366231-70-0

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DB2115 (DB 2115)

Catalog No.: PC-62745Not For Human Use, Lab Use Only.

DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM.
    DB2115 decrease cell growth (IC50=3.4 uM) and the clonogenic capacity of AML cells and leads to increased apoptosis, while showing little effect on normal hematopoietic cells.
    DB2115 decreases tumor burden and increases survival in murine and human AML transplantation models.

    Physicochemical Properties

    M.Wt 558.646
    Formula C32H30N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2,2'-((butane-1,4-diylbis(oxy))bis(4,1-phenylene))bis(1H-benzo[d]imidazole-6-carboximidamide)

    References

    1. Antony-Debré I, et al. J Clin Invest. 2017 Oct 30. pii: 92504.

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