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Chemical Structure : GPI 16552
Catalog No.: PC-62411Not For Human Use, Lab Use Only.
GPI 16552 is a potent, specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with IC50 of 1.7 uM.
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GPI 16552 is a potent, specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with IC50 of 1.7 uM.
GPI 16552 significantly reduces the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, cytokine production (TNF-alpha and IL-1beta), and apoptosis in mice.
| M.Wt | 502.614 | |
| Formula | C33H30N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lu XC, et al. Brain Res. 2003 Jul 18;978(1-2):99-103.
2. Cuzzocrea S, et al. J Pharmacol Exp Ther. 2006 Oct;319(1):127-38.
3. Falsig J, et al. Eur J Pharmacol. 2004 Aug 16;497(1):7-16.
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