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GPI 16552

Chemical Structure : GPI 16552

CAS No.: 443794-40-9

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GPI 16552 (GPI-16552)

Catalog No.: PC-62411Not For Human Use, Lab Use Only.

GPI 16552 is a potent, specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with IC50 of 1.7 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GPI 16552 is a potent, specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with IC50 of 1.7 uM.
    GPI 16552 significantly reduces the degree of spinal cord inflammation and tissue injury, neutrophil infiltration, cytokine production (TNF-alpha and IL-1beta), and apoptosis in mice.

    Physicochemical Properties

    M.Wt 502.614
    Formula C33H30N2O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    9-oxo-N,N'-bis(3-phenylpropyl)-9H-Fluorene-2,7-dicarboxamide

    References

    1. Lu XC, et al. Brain Res. 2003 Jul 18;978(1-2):99-103.

    2. Cuzzocrea S, et al. J Pharmacol Exp Ther. 2006 Oct;319(1):127-38.

    3. Falsig J, et al. Eur J Pharmacol. 2004 Aug 16;497(1):7-16.

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