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CI-976

Chemical Structure : CI-976

CAS No.: 114289-47-3

CI-976 (PD 128042)

Catalog No.: PC-62403Not For Human Use, Lab Use Only.

CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM, also inhibits sterol O-acyltransferase 1 (SOAT1) with IC50 of 6.95 uM (hSOAT1).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM, also inhibits sterol O-acyltransferase 1 (SOAT1) with IC50 of 6.95 uM (hSOAT1).
CI-976 decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits.

Physicochemical Properties

M.Wt 393.568
Formula C23H39NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)-dodecanamide

References

1. Field FJ, et al. Lipids. 1991 Jan;26(1):1-8.

2. O'Brien PM, et al. J Med Chem. 1994 Jun 10;37(12):1810-22.

3. Krause BR, et al. J Lipid Res. 1993 Feb;34(2):279-94.

4. Baba T, et al. Mol Cell Biochem. 2013 Apr;376(1-2):151-61.

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