Catalog No.: PC-62403Not For Human Use, Lab Use Only.
CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor of ACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM, also inhibits sterol O-acyltransferase 1 (SOAT1) with IC50 of 6.95 uM (hSOAT1).
CI-976 (PD 128042) is a potent, selective, orally bioavailable inhibitor ofACAT-1 (Acetyl-CoA acetyltransferase 1) with IC50 of 73 nM, also inhibits sterol O-acyltransferase 1 (SOAT1) with IC50 of 6.95 uM (hSOAT1).
CI-976 decreases plasma total cholesterol, very low density lipoprotein (VLDL) cholesterol, LDL cholesterol, apolipoprotein B, liver cholesteryl esters, and VLDL and LDL cholesteryl ester content in rabbits.
