Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-PDD 00017273
PDD 00017273

Chemical Structure : PDD 00017273

CAS No.: 1945950-21-9

PDD 00017273 (PDDX-001, PDD00017273)

Catalog No.: PC-62412Not For Human Use, Lab Use Only.

PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.

Packing Price Stock Quantity
5 mg $98 In stock
10 mg $148 In stock
25 mg $268 In stock
50 mg $458 In stock
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PDD 00017273 (PDDX-001) is the first-in-class, selective inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with Kd, biochemical EC50 of 1.45 nM, 26 nM.
PDD 00017273 inhibits the proliferation of ZR-75-1 cells and MDA-MB-436 with IC50 of 0.2 and 0.8 uM.
PDD 00017273 inhibits DNA repair with differential pharmacology to olaparib; shows no activity against CYP450 isoforms.
PDD 00017273 possesses good aqueous solubility and suitable for in vivo studies.

Physicochemical Properties

M.Wt 514.619
Formula C23H26N6O4S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide

References

1. James DI, et al. ACS Chem Biol. 2016 Nov 18;11(11):3179-3190.

2. Gravells P, et al. DNA Repair (Amst). 2017 Apr;52:81-91.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: