Chemical Structure : XJB-5-131
CAS No.:
866404-31-1
XJB-5-131
Catalog No.: PC-28360Not For Human Use, Lab Use Only.
XJB-5-131 is hemigramicidin-TEMPO conjugate and mitochondria-targeted ROS and electron scavenger, reduces apoptosis and enhances cell survival in mouse embryonic cells in vitro, improves mitochondrial function.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
XJB-5-131 is hemigramicidin-TEMPO conjugate and mitochondria-targeted ROS and electron scavenger, reduces apoptosis and enhances cell survival in mouse embryonic cells in vitro, improves mitochondrial function.
XJB-5-131 ameliorate intestinal mucosal injury and prolong survival in rats subjected to lethal hemorrhage.
XJB-5-131 significantly suppresses the disease phenotypes and improves mitochondrial function in mouse model of Huntington's disease (HD).
XJB-5-131 suppresses weight loss and improves motor performance.
XJB-5-131 reduces mtDNA damage and maintains mtDNA copy number.
XJB-5-131 improves mitochondrial function in HD150KI animals.
XJB-5-131 protects against 2,3-dimethoxy-1,4-naphthoquinone (DMNQ)-induced loss of mitochondrial spare respiratory capacity (SRC).
Physicochemical Properties
|
M.Wt
|
960.25
|
|
Formula
|
C53H81N7O9
|
|
Appearance
|
Solid
|
|
CAS No.
|
|
|
Storage
|
- Solide Powder
-
-20°C 12 Months; 4°C 6 Months
|
- In Solvent
-
-80°C 6 Months; -20°C 6 Months
|
|
Shipping
|
|
|
Solubility
|
10 mM in DMSO
|
|
Chemical Name/SMILES
|
tert-Butyl ((4S,7S,E)-7-benzyl-8-((S)-2-(((S)-1-(((S)-5-(((benzyloxy)carbonyl)amino)-1-oxo-1-((2,2,6,6-tetramethyl-1-(l1-oxidanyl)piperidin-4-yl)amino)pentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamoyl)pyrrolidin-1-yl)-2-methyl-8-oxooct-5-en-4-yl)carbamate
|
References
1. Xun Z, et al. Cell Rep. 2012 Nov 29;2(5):1137-42.
2. Macias CA, et al. Ann Surg. 2007 Feb;245(2):305-14.
3. Fink MP, et al. Biochem Pharmacol. 2007 Sep 15;74(6):801-9.
Contact Us
sales@probechem.com
