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BRD8899

Chemical Structure : BRD8899

CAS No.: 1404437-50-8

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BRD8899 (BRD-8899, BRD 8899)

Catalog No.: PC-62028Not For Human Use, Lab Use Only.

BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BRD8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP).
    BRD8899 exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%.
    BRD8899 shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells.

    Physicochemical Properties

    M.Wt 362.45
    Formula C17H22N4O3S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(((2S,4R)-4-(4-Methylisoquinoline-5-sulfonamido)pyrrolidin-2-yl)methyl)acetamide

    References

    1. Luo T, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5.

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