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Chemical Structure : BRD8899
Catalog No.: PC-62028Not For Human Use, Lab Use Only.
BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP).
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BRD8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP).
BRD8899 exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%.
BRD8899 shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells.
| M.Wt | 362.45 | |
| Formula | C17H22N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Luo T, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5.
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