YB-B1

Chemical Structure : YB-B1

Catalog No.: PC-25207Not For Human Use, Lab Use Only.

YB-B1 is a small molecule Y-box-binding protein 1 (YBX1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM.

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Biological Activity

YB-B1 is a small molecule Y-box-binding protein 1 (YBX1) inhibitor, directly binds to YBX1 protein with SPR KD value of 5.67 uM.
YB-B1 significantly suppresses proliferation of HEY and OV90 cells with IC50 of 3.5 and 11.9 uM respectively.
YB-B1 decreases the expression of CCNL2 and YBX1.
YB-B1 exhibits a synergistic effect with cisplatin, enhances chemotherapy-induced cytotoxicity in ovarian cancer cells and the PDX model.

Physicochemical Properties

M.Wt	388.43
Formula	C21H20N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N5-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-2-ylmethyl)-1H-imidazole-4,5-dicarboxamide

References

1. Zhang K, et al. J Ovarian Res. 2025 Jul 24;18(1):162.

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YB-B1

Biological Activity

Physicochemical Properties

References

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